On her campaign website, under the heading "Right to Life" Mary Ann Mendoza indicated: "I am pro-life."

In response to a survey for the Center for Arizona Policy 2024 Voter Guide, Mary Ann Mendoza indicated that she opposes Amending the Arizona State Constitution to grant a fundamental right to every individual to an abortion. She also indicated opposition to using taxpayer funds to support any organization that performs, promotes, or provides referrals for abortion.